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Germline mutations in CDH1 are infrequent in women with early-onset or familial lobular breast cancers
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- Published on: 25 January 2011
- Published on: 25 January 2011E-Cadherin (CDH1) exon deletion in lobular breast carcinomaShow More
It was with great interest that we read the recent article by Schrader et al. on the low frequency of CDH1 mutations in early-onset and familial lobular breast cancer (1). As detailed by Schrader et al., the cancer syndrome hereditary diffuse gastric cancer (HDGC), in addition to a high risk of diffuse gastric cancer (DGC), is associated with an increased risk of lobular breast carcinoma, a specific histological subtype of...
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