Current clinical criteria for Lynch syndrome are not sensitive enough to identify MSH6 mutation carriers

Wenche Sjursen; Bjørn Ivar Haukanes; Eli Marie Grindedal; Harald Aarset; Astrid Stormorken; Lars F Engebretsen; Christoffer Jonsrud; Inga Bjørnevoll; Per Arne Andresen; Sarah Ariansen; Liss Anne S Lavik; Bodil Gilde; Inger Marie Bowitz-Lothe; Lovise Mæhle; Pål Møller

doi:10.1136/jmg.2010.077677

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Original article

Current clinical criteria for Lynch syndrome are not sensitive enough to identify MSH6 mutation carriers

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	Abstract	Full	Pdf
Jun 2010	40	11	9
Jul 2010	186	75	85
Aug 2010	483	256	168
Sep 2010	650	503	302
Oct 2010	295	280	170
Nov 2010	37	61	54
Dec 2010	40	28	40
Jan 2011	43	25	35
Feb 2011	46	22	39
Mar 2011	29	43	48
Apr 2011	18	16	33
May 2011	10	9	19
Jun 2011	16	15	29
Jul 2011	53	25	17
Aug 2011	28	16	25
Sep 2011	31	22	18
Oct 2011	40	23	17
Nov 2011	29	27	16
Dec 2011	33	20	12
Jan 2012	22	9	9
Feb 2012	22	4	9
Mar 2012	16	10	13
Apr 2012	26	13	21
May 2012	18	12	9
Jun 2012	21	11	12
Jul 2012	18	9	23
Aug 2012	25	14	11
Sep 2012	31	14	12
Oct 2012	29	17	15
Nov 2012	20	14	11
Dec 2012	17	17	11
Jan 2013	45	26	13
Feb 2013	15	9	6
Mar 2013	19	8	13
Apr 2013	28	15	12
May 2013	20	16	9
Jun 2013	6	6	5
Jul 2013	23	8	12
Aug 2013	14	2	4
Sep 2013	6	3	4
Oct 2013	10	13	6
Nov 2013	9	5	6
Dec 2013	15	10	11
Jan 2014	9	10	9
Feb 2014	19	15	17
Mar 2014	16	13	11
Apr 2014	27	10	10
May 2014	10	15	8
Jun 2014	7	10	9
Jul 2014	17	12	16
Aug 2014	16	12	13
Sep 2014	16	16	8
Oct 2014	12	27	13
Nov 2014	12	15	19
Dec 2014	9	6	8
Jan 2015	5	6	7
Feb 2015	11	6	4
Mar 2015	10	10	5
Apr 2015	11	24	8
May 2015	4	11	6
Jun 2015	13	11	12
Jul 2015	25	11	10
Aug 2015	17	16	10
Sep 2015	25	11	11
Oct 2015	19	7	6
Nov 2015	22	13	10
Dec 2015	27	12	6
Jan 2016	20	9	5
Feb 2016	26	20	12
Mar 2016	22	14	18
Apr 2016	11	4	6
May 2016	10	12	15
Jun 2016	17	15	24
Jul 2016	17	11	22
Aug 2016	19	10	11
Sep 2016	23	13	14
Oct 2016	22	14	11
Nov 2016	20	11	9
Dec 2016	12	16	4
Jan 2017	24	20	11
Feb 2017	5	13	16
Mar 2017	2	13	5
Apr 2017	4	27	8
May 2017	3	27	14
Jun 2017	9	16	8
Jul 2017	24	22	14
Aug 2017	22	21	16
Sep 2017	21	20	8
Oct 2017	22	18	1
Nov 2017	25	23	9
Dec 2017	21	13	9
Jan 2018	15	15	4
Feb 2018	38	23	5
Mar 2018	28	28	16
Apr 2018	25	17	17
May 2018	29	25	11
Jun 2018	34	24	9
Jul 2018	31	23	17
Aug 2018	64	46	13
Sep 2018	54	48	16
Oct 2018	91	86	5
Nov 2018	101	97	22
Dec 2018	79	71	13
Jan 2019	78	63	16
Feb 2019	76	67	17
Mar 2019	24	24	15
Apr 2019	18	14	20
May 2019	21	16	21
Jun 2019	23	15	10
Jul 2019	25	20	24
Aug 2019	18	8	12
Sep 2019	21	15	13
Oct 2019	16	14	5
Nov 2019	9	9	5
Dec 2019	17	16	12
Jan 2020	30	20	19
Feb 2020	13	9	37
Mar 2020	28	20	12
Apr 2020	19	19	14
May 2020	10	10	6
Jun 2020	6	6	4
Jul 2020	16	10	3
Aug 2020	15	13	4
Sep 2020	39	37	9
Oct 2020	14	14	10
Nov 2020	28	20	15
Dec 2020	29	21	8
Jan 2021	24	15	17
Feb 2021	27	24	27
Mar 2021	16	13	10
Apr 2021	17	11	10
May 2021	22	17	4
Jun 2021	14	14	5
Jul 2021	9	10	16
Aug 2021	4	13	5
Sep 2021	14	22	9
Oct 2021	23	28	24
Nov 2021	17	20	27
Dec 2021	16	16	17
Jan 2022	19	13	13
Feb 2022	10	11	8
Mar 2022	19	16	12
Apr 2022	22	17	10
May 2022	29	27	23
Jun 2022	33	28	9
Jul 2022	24	20	7
Aug 2022	35	29	9
Sep 2022	39	36	13
Oct 2022	36	32	11
Nov 2022	26	24	11
Dec 2022	38	32	6
Jan 2023	45	37	10
Feb 2023	58	46	13
Total	5160	3977	2684

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