Article Text
Abstract
Background: Telomere length is a predictor for a number of common age related diseases and is a heritable trait.
Methods and results: To identify new loci associated with mean leukocyte telomere length we conducted a genome wide association study of 314 075 single nucleotide polymorphisms (SNPs) and validated the results in a second cohort (n for both cohorts combined = 2790). We identified two novel associated variants (rs2162440, p = 2.6×10−6; and rs7235755, p = 5.5×10−6) on chromosome 18q12.2 in the same region as the VPS34/PIKC3C gene, which has been directly implicated in the pathway controlling telomere length variation in yeast.
Conclusion: These results provide new insights into the pathways regulating telomere homeostasis in humans.
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Footnotes
MM and JBR contributed equally to this work
Funding: This study was funded in part by: the Wellcome Trust; NIHR (TDS), NIHR Biomedical Research Centre (grant to Guys’ and St. Thomas’ Hospitals and King’s College London)
Competing interests: None declared.