Responses

Download PDFPDF

Investigation of somatic NKX2-5 mutations in congenital heart disease
Compose Response

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Statement of Competing Interests

PLEASE NOTE:

  • Responses are moderated before posting and publication is at the absolute discretion of BMJ, however they are not peer-reviewed
  • Once published, you will not have the right to remove or edit your response. Removal or editing of responses is at BMJ's absolute discretion
  • If patients could recognise themselves, or anyone else could recognise a patient from your description, please obtain the patient's written consent to publication and send them to the editorial office before submitting your response [Patient consent forms]
  • By submitting this response you are agreeing to our full [Response terms and requirements]

Vertical Tabs

Other responses

Jump to comment:

  • Published on:
    Response to Borlak eletter

    ----------------------------------------------------------------- "Commentary on investigations of somatic NKX2-5 mutations in congenital heart disease (CHD) " -----------------------------------------------------------------

    Somatic mutations in transcription factor genes pertinent to cardiac tissue development have been put forward as a molecular rationale of CHD. Nkx2-5 is a homeodomain-containing transcription...

    Show More
    Conflict of Interest:
    None declared.
  • Published on:
    Commentary on investigations of somatic NKX2-5 mutations in congenital heart disease (CHD)
    • Juergen Borlak, Director
    • Other Contributors:
      • Stella Marie Reamon-Buettner

    Somatic mutations in transcription factor genes pertinent to cardiac tissue development have been put forward as a molecular rationale of CHD. Nkx2-5 is a homeodomain-containing transcription factor and is conserved in many organisms from flies to humans. It is an important transcriptional regulator of mammalian heart development. Absence of Nkx2-5 in animal models results in lethality due to impaired heart tube looping (...

    Show More
    Conflict of Interest:
    None declared.