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Lugtenberg D, de Brouwer APM, Kleefstra T, Oudakker AR, Frints SGM, Schrander-Stumpel CTRM, Fryns JP, Jensen LR, Chelly J, Moraine C, Turner G, Veltman JA, Hamel BCJ, de Vries BBA, van Bokhoven H, Yntema HG. Chromosomal copy number changes in patients with non-syndromic X linked mental retardation detected by array CGH. J Med Genet 2006;43:362–70.
There was an error in an article published in the April 2006 issue of the journal. The authors reported possible duplication of copy number polymorphisms flanking the MECP2 region. These duplications were observed by multiplex ligation-dependent probe amplification (MLPA) in one patient and two controls (figure 2). Recent further investigations of these regions have shown that these duplications were false observations. Newly synthesised MLPA probes and better quality DNA samples showed no extra DNA copies in the region. From reanalysis of the previously obtained MLPA data, the authors conclude that the fluorescence intensity signals were outside the normal range in which the data can be correctly interpreted (100–1000) for current quality-control thresholds (>10000). The authors regret this incorrect interpretation of the data.
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