In response to a previous article outlining the search for other genes causing Li–Fraumeni syndrome (LFS),1 we have some evidence to suggest that BRCA2 may in some circumstances cause a Li–Fraumeni-like (LFL) pattern. Extensive analysis of classical LFS families has shown 70–75% with complete gene sequencing have identifiable mutations.1^–3 A lower, but nevertheless substantial, proportion (30–40%) of families fulfilling criteria for LFL syndrome (box 1)2 also carry TP53 mutations. A recent paper has also suggested that BRCA2 may cause a fraction of breast sarcoma families.4 We have re-investigated an extensive LFL family (family 80) in whom we previously excluded TP53 by sequencing of all exons and by linkage5 and identified an exon 14–16 deletion in BRCA2.