The gene for insulin-degrading enzyme (IDE), which is located at chromosome 10q24, has been previously proposed as a candidate gene for late-onset Alzheimer’s disease (AD) based on its ability to degrade amyloid β-protein. Genotyping of single nucleotide polymorphisms (SNPs) in the IDE gene in Finnish patients with AD and controls revealed SNPs rs4646953 and rs4646955 to be associated with AD, conferring an approximately two-fold increased risk. Single locus findings were corroborated by the results obtained from haplotype analyses. This suggests that genetic alterations in or near the IDE gene may increase the risk for developing AD.
- AD, Alzheimer’s disease
- APOE, apolipoprotein E
- IDE, insulin-degrading enzyme
- LD, linkage disequilibrium
- SNP, single nucleotide polymorphism
- Alzheimer’s disease
- insulin-degrading enzyme (IDE)
- risk gene
- single nucleotide polymorphism (SNP)
Statistics from Altmetric.com
Competing interests: None declared.
Ethics approval: The Ethics Committee of Kuopio University Hospital and Kuopio University approved the study.
Published Online First 11 May 2007
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.