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Response to correspondence on “Phenocopies in BRCA1 and BRCA2 families: evidence for modifier genes and implications for screening”
  1. A Smith1,
  2. M C Boyd1,
  3. M Bulman1,
  4. A Shenton1,
  5. F Lalloo1,
  6. D G R Evans1,
  7. A Moran2,
  8. R Iddenden2,
  9. L Smith3,
  10. E R Woodward3,
  11. E R Maher3
  1. 1Academic Unit of Medical Genetics and Regional Genetics Service, St Mary’s Hospital, Manchester, UK
  2. 2North Western Cancer Registry, Center for Cancer Epidemiology, Christie Hospital, Manchester, UK
  3. 3Section of Medical and Molecular Genetics, University of Birmingham School of Medicine; West Midlands Regional Genetics Service, Birmingham, UK
  1. Correspondence to:
 Dr D G R Evans
 Academic Unit of Medical Genetics and Regional Genetics Service, St Mary’s Hospital, Hathersage Road, Manchester, M13 0JH, UK; gareth.evans{at}

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We wish to reply to the interesting comments concerning our paper on phenocopies in families positive for mutations in BRCA1/2 genes since its electronic publication in October 2006.1 We understand the reservations about changing practice in reassuring individuals who test negative for a family mutation based on one largely retrospective analysis of families, and clearly there is a need to confirm our results in other large series. We were particularly careful to obviate …

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