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No screening yet after a negative test for the family mutation
  1. M M A Tilanus-Linthorst
  1. Correspondence to:
 Department of Surgery
 Erasmus MC, Rotterdam, The Netherlands; m.tilanus-linthorst{at}

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In their interesting paper, Smith et al1 postulate that after a negative test for BRCA1 and BRCA2, women are still at increased risk of cancer. They therefore recommend to continue screening.

I think there are several reasons why surveillance recommendations, after a negative test for the family mutation, are premature.

(1) It should be clear how high the rest risk is. This …

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