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Correspondence
No screening yet after a negative test for the family mutation
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In their interesting paper, Smith et al1 postulate that after a negative test for BRCA1 and BRCA2, women are still at increased risk of cancer. They therefore recommend to continue screening.
I think there are several reasons why surveillance recommendations, after a negative test for the family mutation, are premature.
(1) It should be clear how high the rest risk is. This …