Article Text

Download PDFPDF
Altered CD45 expression in C77G carriers influences immune function and outcome of hepatitis C infection


Background: A polymorphism in exon 4 (C77G) of CD45 that alters CD45 splicing has been associated with autoimmune and infectious diseases in humans.

Objective: To investigate the effect of C77G in hepatitis C virus (HCV) infected individuals and study the phenotype and function of peripheral blood mononuclear cells (PBMC) from healthy and hepatitis C infected C77G carriers.

Results: C77G individuals showed an increased proportion of primed CD45RA and effector memory CD8 T cells and more rapid activation of the lymphocyte specific protein tyrosine kinase (Lck) following CD3 stimulation. Transgenic mice with CD45 expression mimicking that in human C77G variants had more activated/memory T cells, more rapid proliferative responses, and activation of Lck.

Conclusions: Changes in CD45 isoform expression can alter immune function in human C77G variants and CD45 transgenic mice. The C77G allele may influence the outcome of HCV infection.

  • HCV, hepatitis C virus
  • HENCORE, Hepatitis C European Network for Cooperative Research
  • Lck, lymphocyte specific protein tyrosine kinase
  • PBMC, peripheral blood mononuclear cells
  • SNP, single nucleotide polymorphism
  • TcR, T cell receptor
  • CD45
  • C77G variant
  • hepatitis C
  • immune response

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.