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Analysis of RUNX1 binding site and RAPTOR polymorphisms in psoriasis: no evidence for association despite adequate power and evidence for linkage
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  • Published on:
    Authors' response to Bowcock et al.
    • James T. Elder, physician-scientist
    • Other Contributors:
      • Philip E. Stuart, Rajan P. Nair, Gonçalo R. Abecasis, Ioana Nistor, Ravi Hiremagalore, Nicholas V. Chia Zhaohui S. Qin, Rachel A. Thompson, Stefan Jenisch, Michael Weichenthal, Jennifer Janiga, Henry W. Lim, Enno Christophers,and John J.Voorhees

    Dear Editor,

    In response to the comments of Helms et al.: We recognize that in the presence of substantial heterogeneity, much larger sample sizes may be required to replicate an effect. Thus, we cannot rule out the possibility that the variants in the RUNX binding site and the RAPTOR gene make a substantial contribution to psoriasis susceptibility in some settings. Nevertheless, in our sample, which includes...

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    Conflict of Interest:
    None declared.
  • Published on:
    Analysis of RUNX1 binding site and RAPTOR polymorphisms in psoriasis
    • Anne M. Bowcock, Professor
    • Other Contributors:
      • Cynthia Helms, Li Cao, James G. Krueger, Ellen M .Wijsman, Derek Gordon, Michael Heffernan, Jason Robarge1, Jurg Ott, Pui Y. Kwok, Alan Menter

    Dear Editor,

    In the recently published report "Analysis of RUNX1 Binding Site and RAPTOR Polymorphisms in Psoriasis: No Evidence for Association Despite Adequate Power and Evidence for Linkage"[1] the authors report failure to see association of psoriasis susceptibility to a region of chromosome 17q25. This region was first identified with linkage analysis by our group[2], and we recently reported evidence for a...

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    Conflict of Interest:
    None declared.