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Electronic letters
Potential for expanded power in linkage studies using the ALLEGRO and MERLIN software programs
  1. E Rampersaud,
  2. W K Scott,
  3. E R Hauser,
  4. M C Speer
  1. Center for Human Genetics, Duke University Medical Center, Durham, NC, USA
  1. Correspondence to:
 Dr Marcy C Speer
 Duke University Medical Center, Box 3445, Durham, NC 27710, USA; marcy{at}chg.duhs.duke.edu

Abstract

Multipoint linkage analysis in complex diseases requires the use of fast algorithms that can handle many markers and a large number of moderately sized pedigrees with unknown mode of inheritance. This need has led to the development of several competitive software programs. We recently completed a genomic screen of neural tube defects using GENEHUNTER-PLUS and the more recent ALLEGRO. The ALLEGRO software was found to offer expanded power for linkage studies, particularly for childhood onset diseases like neural tube defects, though the results must be treated with caution.

  • GH+, GENEHUNTER-PLUS
  • NTD, neural tube defect
  • ALLEGRO
  • MERLIN
  • linkage
  • multipoint

https://doi.org/10.1136/jmg.2005.032029

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    Footnotes

    • This work was supported by a Ruth L Kirschstein National Research Service Awards predoctoral fellowship (NS046249) and by grants from the National Institutes of Health (NS39818, HD39948, ES11375, ES011961).

    • Competing interests: none declared