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5,10-methylenetetrahydrofolate reductase (MTHFR) 677C→T and 1298A→C mutations are associated with DNA hypomethylation

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  • This study was partially supported by a grant awarded to Rita Azevedo e Castro (Praxis XXI/BD/11383/97) by the Fundação para a Ciência e Tecnologia. Henk Blom is supported by the Netherlands Heart Foundation.

  • Conflicts of interest: none declared.