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  • Female preclinical presenilin-1 mutation carriers unaware of their genetic status have higher levels of depression than their non-mutation carrying kin

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Female preclinical presenilin-1 mutation carriers unaware of their genetic status have higher levels of depression than their non-mutation carrying kin
  1. J M Ringman,
  2. C Diaz-Olavarrieta,
  3. Y Rodriguez,
  4. M Chavez,
  5. F Paz,
  6. J Murrell,
  7. M Angel Macias,
  8. M Hill,
  9. C Kawas

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      Objectives: To study depressive symptoms in preclinical presenilin-1 (PS1) related Alzheimer’s disease.

      Methods: Participants were 33 Mexican women at risk for inheriting PS1 mutations who were not demented. They were interviewed, underwent cognitive testing, and completed the Beck depression inventory (BDI). …

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