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Aetiology of colorectal cancer and relevance of monogenic inheritance
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  1. M Ponz de Leon,
  2. P Benatti,
  3. F Borghi,
  4. M Pedroni,
  5. A Scarselli,
  6. C Di Gregorio,
  7. L Losi,
  8. A Viel,
  9. M Genuardi,
  10. G Abbati,
  11. G Rossi,
  12. M Menigatti,
  13. I Lamberti,
  14. G Ponti,
  15. L Roncucci
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      Background and aims: Although diet and lifestyle are associated with the development of colorectal malignancies, the only clearly identified aetiological factors in colorectal cancer are inheritance (hereditary non-polyposis colorectal cancer (HNPCC) and familial polyposis), inflammatory bowel diseases, papillomavirus, and acquired immunodeficiency syndrome (AIDS). Our aim was to determine what proportion of colorectal neoplasms could be attributed to these …

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      Copyright 2004 Journal of Medical Genetics