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A locus for autosomal dominant keratoconus maps to human chromosome 3p14–q13
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  • Published on:
    Reply to: "Diagnostic criteria of forme fruste keratoconus"
    • Antonio Pizzuti, Doctor
    • Other Contributors:
      • Francesco Brancati, Enza Maria Valente, Anna Sarkozy, Jànos Fehèr, Marco Castori, Pietro Del Duca, Rita Mingarelli, Antonio Pizzuti and Bruno Dallapiccola

    Dear Editor              

    We thank the authors for their comments on our Letter to the Editor describing a novel locus for autosomal dominant keratoconus on chromosome 3 [1]. We thoroughly agree with the author’s opinion that simple astigmatism should not be considered a diagnostic criteria for forme fruste KC. However, none of our 4 patients diagnosed with forme fruste KC had simple astigmatism. In these patients, t...

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    Conflict of Interest:
    None declared.
  • Published on:
    Diagnostic criteria of forme fruste keratoconus.
    • Petra Liskova, Ophthalmologist
    • Other Contributors:
      • Neil D. Ebenezer, Stephen J. Tuft and Shomi S. Bhattacharya

    Dear Editor

    We would like to comment on the letter describing linkage analysis in autosomal dominant keratoconus presented by Brancati et al. in the March issue of JMG [1]. The pedigree includes 4 patients with forme fruste keratoconus and Figure 2 shows the videokeratography of patient III:9 to support this diagnosis. However, from the data presented this patient appears to have unilateral simple astigmatism, whi...

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    Conflict of Interest:
    None declared.