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This study was supported by the Deutsche Forschungsgemeinschaft (Klinische Forschergruppe Ophthalmologische Onkologie und Genetik, DFG KFO 109/1-1, TP II-1).
Conflict of interest: none declared.
Ethics approval: Diagnostic mutation analysis was performed conforming to national guidelines. Scientific analysis of the data was approved by the ethics committee of the Medizinische Fakultät der Universität Essen (file # 01-100-1700).