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Correction: no evidence of an association between the T16189C mtDNA variant and late onset dementia (Gibson et al)
  1. J Poulton,
  2. S Das
  1. Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Women’s Centre, John Radcliffe Hospital, Oxford, UK
  1. Correspondence to:
 Professor J Poulton
 Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Women’s Centre, John Radcliffe Hospital, Oxford, OX3 9DU, UK; joanna.poultonobs-gyn.ox.ac.uk

https://doi.org/10.1136/jmg.2004.019208

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    We believe that the title of Chinnery et al’s paper should be corrected because the data the authors present do not include an analysis of the 16189 variant of mtDNA (Table 1).

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    Table 1

     Sequences of identified variants

    We defined the 16189 variant as the DNA sequence associated with a polydC tract,2 resulting from a T16189C transition that may generate heteroplasmic length variation, table 1. Heteroplasmic length variation does not occur when the polymeric tract is interrupted by a c→t transition, which occurs at several different sites but commonly at nucleotice 16186 or …

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    • Conflict of interest: none declared