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Association between a functional polymorphism in the serotonin transporter gene and diarrhoea predominant irritable bowel syndrome in women
  1. A Yeo,
  2. P Boyd,
  3. S Lumsden,
  4. T Saunders,
  5. A Handley,
  6. M Stubbins,
  7. A Knaggs,
  8. S Asquith,
  9. I Taylor,
  10. B Bahari,
  11. N Crocker,
  12. R Rallan,
  13. S Varsani,
  14. D Montgomery,
  15. D H Alpers,
  16. G E Dukes,
  17. I Purvis,
  18. G A Hicks

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    Background and aims: Serotonin (5-hydroxtryptamine, 5-HT) is an important factor in gut function, playing key roles in intestinal peristalsis and secretion, and in sensory signalling in the brain-gut axis. Removal from its sites of action is mediated by a specific protein called the serotonin reuptake transporter (SERT or 5-HTT). …

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