Article Text

Download PDFPDF
BRAF mutations in cholangiocarcinoma

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Intrahepatic cholangiocarcinoma is the second most common primary hepatic malignant neoplasm, after hepatocellular carcinoma. Retrovirus-associated DNA sequences (RAS), controlled by RAS oncogenes, works at least in part through the mitogen activated protein kinase (MAPK) signal transduction cascade. Signalling through this cascade leads to activation of RAF kinase. Mammalian cells contain three RAF isoforms, …

View Full Text