Intrahepatic cholangiocarcinoma is the second most common primary hepatic malignant neoplasm, after hepatocellular carcinoma. Retrovirus-associated DNA sequences (RAS), controlled by RAS oncogenes, works at least in part through the mitogen activated protein kinase (MAPK) signal transduction cascade. Signalling through this cascade leads to activation of RAF kinase. Mammalian cells contain three RAF isoforms, …