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Evaluation of breast cancer risk assessment packages in the family history evaluation and screening programme
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  • Published on:
    Breast cancer risk prediction models
    • Mano S Selvan, Department of Biostatistics and Applied Mathematics

    Dear Editor

    I would like to bring to your attention an error with respect to the original article by Amir et al.[1]

    The paper validated a few available breast cancer risk prediction models and compared them to the Tyrer-Cuzick model.[2] From the paper by Amir et al., I understand that they used the Cyrillic plug-in to estimate breast cancer risk (Cyrillic 3.1 Version). Although, I am only fa...

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    Conflict of Interest:
    None declared.
  • Published on:
    Re: Breast cancer risk prediction models
    • D Gareth Evans, Professor
    • Other Contributors:
      • E Amir, A Shenton, A Howell

    Dear Editor

    We thank Dr Selvan for his comments [1] on our paper.[2] Cyrillic 3 does indeed use the BRCAPRO and MENDEL models. With regards to our use of BRCAPRO, we would like to draw his attention to the official Cyrillic 3 homepage [3] where it states clearly that the BRCAPRO plug-in calculates risk based on the “Bayes’ rules of determination of the probability of a mutation, given family history. An estimate of th...

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    Conflict of Interest:
    None declared.