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Genotype-phenotype analysis of the Crohn’s disease susceptibility haplotype on chromosome 5q31
  1. A Armuzzi,
  2. T Ahmad,
  3. K-L Ling,
  4. A de Silva,
  5. S Cullen,
  6. D van Heel,
  7. T R Orchard,
  8. K I Welsh,
  9. S E Marshall,
  10. D P Jewell

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    Background and aims: Recent molecular data suggest that genetic factors may underlie the disease heterogeneity observed in both ulcerative colitis (UC) and Crohn’s disease (CD). A locus on chromosome 5q has been implicated in susceptibility to CD, and recently refined by linkage disequilibrium mapping to a conserved 250 kb haplotype (5q31). No data regarding the …

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