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UGT1A7 and colorectal cancer susceptibility

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Direct evidence that sporadic colorectal cancers (CRCs) can arise from an interaction between genes and environment has come from a study of gene variation affecting the power of an enzyme to detoxify known carcinogens.

Identification of genetic polymorphisms of the human UDP-glucuronosyltransferase (UGT)1A7 gene—a new risk factor—may also improve primary …

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