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HLA-DR4 and risk of spondyloarthropathy

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French investigators have identified in 70 families a second allele predisposing to a group of inflammatory rhematic diseases—the spondyloarthropathies (SpA). MHC HLA-B27 is associated with all familial SpA—ankylosing spondylitis; reactive arthritis; a subspecies of psoriatic arthritis; arthritis with inflammatory bowel disease; and undifferentiated spondyloarthropathy—but now …

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