Mutations in the pancreatic secretory trypsin inhibitor gene (PSTI/SPINK1) rather than the cationic trypsinogen gene (PRSS1) are significantly associated with tropical calcific pancreatitis

G R Chandak; M M Idris; D N Reddy; S Bhaskar; P V J Sriram; L Singh

doi:10.1136/jmg.39.5.347

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Mutations in the pancreatic secretory trypsin inhibitor gene (PSTI/SPINK1) rather than the cationic trypsinogen gene (PRSS1) are significantly associated with tropical calcific pancreatitis

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	Abstract	Full	Pdf
May 2002	0	66	25
Jun 2002	0	34	12
Jul 2002	0	32	20
Aug 2002	0	20	11
Sep 2002	0	12	7
Oct 2002	0	25	13
Nov 2002	0	23	6
Dec 2002	0	10	5
Jan 2003	0	16	18
Feb 2003	0	7	4
Mar 2003	0	9	3
Apr 2003	0	5	5
May 2003	0	17	6
Jun 2003	0	22	4
Jul 2003	0	36	6
Aug 2003	0	26	5
Sep 2003	0	18	10
Oct 2003	0	53	10
Nov 2003	0	26	13
Dec 2003	0	16	7
Jan 2004	0	62	5
Feb 2004	0	11	1
Mar 2004	0	13	2
Apr 2004	0	21	2
May 2004	0	41	5
Jun 2004	0	71	18
Jul 2004	0	70	8
Aug 2004	0	90	20
Sep 2004	0	108	8
Oct 2004	12	46	2
Nov 2004	16	44	14
Dec 2004	15	40	8
Jan 2005	18	31	20
Feb 2005	18	52	12
Mar 2005	15	45	59
Apr 2005	11	18	5
May 2005	9	29	5
Jun 2005	9	18	2
Jul 2005	6	26	3
Aug 2005	9	42	4
Sep 2005	9	39	32
Oct 2005	7	25	13
Nov 2005	10	34	16
Dec 2005	6	39	13
Jan 2006	14	36	7
Feb 2006	7	32	11
Mar 2006	6	25	8
Apr 2006	15	31	13
May 2006	5	19	8
Jun 2006	5	15	5
Jul 2006	5	15	5
Aug 2006	5	8	4
Sep 2006	13	20	12
Oct 2006	4	28	3
Nov 2006	9	23	5
Dec 2006	4	22	5
Jan 2007	8	24	10
Feb 2007	9	28	2
Mar 2007	19	26	7
Apr 2007	16	9	5
May 2007	5	13	9
Jun 2007	15	9	2
Jul 2007	5	9	1
Aug 2007	16	6	1
Sep 2007	8	17	5
Oct 2007	12	14	3
Nov 2007	9	19	9
Dec 2007	5	6	1
Jan 2008	16	10	7
Feb 2008	11	12	10
Mar 2008	17	17	5
Apr 2008	11	15	2
May 2008	18	5	0
Jun 2008	15	1	1
Jul 2008	18	7	4
Aug 2008	11	5	3
Sep 2008	16	12	1
Oct 2008	5	12	2
Nov 2008	6	11	1
Dec 2008	7	5	0
Jan 2009	9	2	1
Feb 2009	18	4	5
Mar 2009	9	11	3
Apr 2009	9	8	3
May 2009	4	11	0
Jun 2009	5	7	3
Jul 2009	5	11	0
Aug 2009	10	7	1
Sep 2009	6	12	2
Oct 2009	11	7	4
Nov 2009	16	9	5
Dec 2009	7	6	3
Jan 2010	12	5	3
Feb 2010	5	3	1
Mar 2010	9	8	1
Apr 2010	11	11	5
May 2010	7	8	2
Jun 2010	6	7	3
Jul 2010	7	1	1
Aug 2010	15	7	3
Sep 2010	11	13	5
Oct 2010	17	20	5
Nov 2010	21	8	0
Dec 2010	17	7	1
Jan 2011	10	5	0
Feb 2011	11	8	0
Mar 2011	18	11	2
Apr 2011	12	15	6
May 2011	45	3	5
Jun 2011	57	12	6
Jul 2011	39	3	7
Aug 2011	17	1	4
Sep 2011	30	10	2
Oct 2011	23	9	2
Nov 2011	37	9	3
Dec 2011	17	17	7
Jan 2012	8	18	11
Feb 2012	15	16	30
Mar 2012	3	13	19
Apr 2012	7	15	3
May 2012	11	29	7
Jun 2012	9	24	5
Jul 2012	10	24	13
Aug 2012	15	25	11
Sep 2012	15	18	6
Oct 2012	14	21	10
Nov 2012	0	24	12
Dec 2012	0	10	10
Jan 2013	0	22	9
Feb 2013	0	8	9
Mar 2013	0	15	17
Apr 2013	0	10	8
May 2013	0	20	12
Jun 2013	8	9	1
Jul 2013	14	15	7
Aug 2013	16	12	4
Sep 2013	10	9	5
Oct 2013	7	7	8
Nov 2013	4	4	9
Dec 2013	10	6	2
Jan 2014	3	9	1
Feb 2014	7	12	4
Mar 2014	31	13	8
Apr 2014	11	23	5
May 2014	18	47	1
Jun 2014	11	22	13
Jul 2014	12	22	4
Aug 2014	7	26	7
Sep 2014	9	35	5
Oct 2014	6	26	3
Nov 2014	4	31	2
Dec 2014	13	19	3
Jan 2015	3	25	1
Feb 2015	11	7	5
Mar 2015	7	21	0
Apr 2015	8	18	7
May 2015	12	22	4
Jun 2015	2	18	2
Jul 2015	4	12	2
Aug 2015	5	5	4
Sep 2015	5	13	11
Oct 2015	7	7	1
Nov 2015	12	2	2
Dec 2015	18	20	7
Jan 2016	19	17	5
Feb 2016	15	13	4
Mar 2016	12	10	7
Apr 2016	9	10	4
May 2016	9	11	6
Jun 2016	10	21	1
Jul 2016	12	16	11
Aug 2016	7	7	4
Sep 2016	12	17	56
Oct 2016	23	15	16
Nov 2016	20	14	4
Dec 2016	23	29	10
Jan 2017	8	20	4
Feb 2017	6	9	4
Mar 2017	9	17	5
Apr 2017	11	34	0
May 2017	5	36	2
Jun 2017	13	28	10
Jul 2017	12	10	4
Aug 2017	27	21	2
Sep 2017	42	28	5
Oct 2017	40	32	6
Nov 2017	45	23	0
Dec 2017	22	12	2
Jan 2018	40	18	2
Feb 2018	35	23	6
Mar 2018	55	35	5
Apr 2018	39	23	4
May 2018	52	38	1
Jun 2018	58	50	6
Jul 2018	25	23	7
Aug 2018	29	27	10
Sep 2018	27	21	6
Oct 2018	36	22	4
Nov 2018	25	19	5
Dec 2018	40	24	6
Jan 2019	44	29	9
Feb 2019	30	25	8
Mar 2019	22	17	5
Apr 2019	27	19	13
May 2019	51	31	17
Jun 2019	24	20	4
Jul 2019	38	25	13
Aug 2019	21	19	6
Sep 2019	20	16	3
Oct 2019	24	20	6
Nov 2019	20	12	7
Dec 2019	24	16	7
Jan 2020	35	28	6
Feb 2020	19	13	5
Mar 2020	14	10	10
Apr 2020	19	12	5
May 2020	30	25	6
Jun 2020	21	11	9
Jul 2020	26	18	8
Aug 2020	9	9	2
Sep 2020	34	26	10
Oct 2020	22	22	5
Nov 2020	41	30	6
Dec 2020	18	14	8
Jan 2021	21	16	2
Feb 2021	19	11	6
Mar 2021	27	17	6
Apr 2021	14	14	8
May 2021	34	27	4
Jun 2021	13	13	5
Jul 2021	17	17	11
Aug 2021	20	20	6
Sep 2021	32	32	9
Oct 2021	35	31	27
Nov 2021	38	28	17
Dec 2021	41	35	5
Jan 2022	46	36	6
Feb 2022	32	27	12
Mar 2022	17	11	5
Apr 2022	33	23	7
May 2022	37	28	17
Jun 2022	43	39	4
Jul 2022	20	18	6
Aug 2022	42	34	7
Sep 2022	35	33	8
Oct 2022	43	33	6
Nov 2022	33	25	2
Dec 2022	26	17	4
Jan 2023	42	32	10
Feb 2023	40	34	3
Mar 2023	27	22	2
Apr 2023	28	20	9
May 2023	21	11	8
Jun 2023	20	16	4
Jul 2023	15	13	8
Aug 2023	13	9	4
Sep 2023	27	21	8
Oct 2023	50	36	5
Nov 2023	57	51	6
Dec 2023	138	11	3
Jan 2024	31	3	0
Feb 2024	35	2	1
Mar 2024	108	5	0
Total	4380	5290	1751

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