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Unlinked genes influence severity of FAP within families

https://doi.org/10.1136/jmg.39.12.905

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    A study of how familial adenomatous polyposis (FAP) varies within families supports the hypothesis that modifier genes affect the severity of the disease. This in turn may provide new insights into tumour formation in the gut.

    Severity of FAP was significantly related to truncation mutations of the APC gene. …

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