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Editor—The genetic counselling of a pregnant woman who carries an Xp chromosomal deletion is far from straightforward. While the precise locations of the CDPX1(arylsulphatase E), steroid sulphatase (STS), and Kallman (KAL1) genes are known and FISH probes are available for these well characterised genes, the positions of putative mental retardation genes in this region have not yet been determined. Clinical and molecular studies undertaken over the past 10 years on patients with distal Xp deletions imply, however, that the putative X linked mental retardation (XLMR) gene,MRX49, lies distal toGS1 and STS but proximal to DXS31 and CDPX1 (fig1).1-4