The −48 C/T polymorphism in the presenilin 1 promoter is associated with an increased risk of developing Alzheimer's disease and an increased Aβ load in brain

Jean-Charles Lambert; David M A Mann; Judith M Harris; Marie-Christine Chartier-Harlin; Alistair Cumming; John Coates; Helen Lemmon; David StClair; Takeshi Iwatsubo; Corinne Lendon

doi:10.1136/jmg.38.6.353

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Original article

The −48 C/T polymorphism in the presenilin 1 promoter is associated with an increased risk of developing Alzheimer's disease and an increased Aβ load in brain

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	Abstract	Full	Pdf
Jun 2001	378	219	40
Jul 2001	14	61	20
Aug 2001	5	45	14
Sep 2001	5	29	6
Oct 2001	0	18	10
Nov 2001	2	32	10
Dec 2001	3	46	4
Jan 2002	4	20	5
Feb 2002	3	12	4
Mar 2002	5	12	4
Apr 2002	3	12	13
May 2002	2	13	3
Jun 2002	0	6	2
Jul 2002	2	2	0
Aug 2002	2	8	6
Sep 2002	4	12	7
Oct 2002	2	7	3
Nov 2002	4	18	5
Dec 2002	1	4	2
Jan 2003	2	13	4
Feb 2003	2	6	6
Mar 2003	2	6	4
Apr 2003	0	15	6
May 2003	4	11	9
Jun 2003	1	7	3
Jul 2003	10	63	1
Aug 2003	9	14	1
Sep 2003	8	11	10
Oct 2003	12	58	6
Nov 2003	11	24	1
Dec 2003	14	14	4
Jan 2004	16	60	2
Feb 2004	8	14	3
Mar 2004	15	23	1
Apr 2004	16	20	7
May 2004	37	40	4
Jun 2004	47	51	2
Jul 2004	55	57	6
Aug 2004	44	52	5
Sep 2004	40	47	1
Oct 2004	25	32	11
Nov 2004	9	22	9
Dec 2004	16	30	14
Jan 2005	9	16	7
Feb 2005	9	18	7
Mar 2005	9	19	10
Apr 2005	2	16	10
May 2005	5	7	4
Jun 2005	4	8	6
Jul 2005	3	10	2
Aug 2005	4	6	7
Sep 2005	3	1	2
Oct 2005	9	12	5
Nov 2005	6	15	7
Dec 2005	3	6	1
Jan 2006	3	10	5
Feb 2006	1	8	5
Mar 2006	6	10	7
Apr 2006	3	10	7
May 2006	2	9	5
Jun 2006	2	3	0
Jul 2006	5	10	4
Aug 2006	5	6	3
Sep 2006	1	5	2
Oct 2006	5	3	3
Nov 2006	3	14	5
Dec 2006	10	15	1
Jan 2007	12	20	5
Feb 2007	4	10	5
Mar 2007	3	10	6
Apr 2007	10	5	3
May 2007	2	2	2
Jun 2007	5	5	2
Jul 2007	1	4	2
Aug 2007	3	4	3
Sep 2007	1	2	1
Oct 2007	6	6	4
Nov 2007	0	1	0
Dec 2007	4	6	5
Jan 2008	1	3	3
Feb 2008	2	6	7
Mar 2008	4	6	7
Apr 2008	2	0	0
May 2008	6	2	1
Jun 2008	1	1	1
Jul 2008	6	1	0
Aug 2008	16	2	0
Sep 2008	13	4	1
Oct 2008	7	0	0
Nov 2008	18	1	1
Dec 2008	5	2	1
Jan 2009	4	0	0
Feb 2009	2	0	3
Mar 2009	8	1	0
Apr 2009	4	0	0
May 2009	3	2	3
Jun 2009	2	0	0
Jul 2009	6	0	0
Aug 2009	2	0	0
Sep 2009	4	0	0
Oct 2009	4	0	0
Nov 2009	10	2	1
Dec 2009	7	1	1
Jan 2010	10	0	3
Mar 2010	6	0	1
Apr 2010	4	0	2
May 2010	5	1	0
Jun 2010	4	0	2
Jul 2010	3	4	0
Aug 2010	1	1	1
Sep 2010	2	3	2
Oct 2010	2	1	1
Nov 2010	5	1	0
Dec 2010	4	1	0
Jan 2011	6	1	0
Feb 2011	6	0	0
Mar 2011	2	0	1
Apr 2011	6	0	0
May 2011	2	0	2
Jun 2011	4	3	2
Jul 2011	4	1	2
Aug 2011	9	1	2
Sep 2011	4	1	1
Oct 2011	5	1	0
Nov 2011	10	1	1
Dec 2011	10	2	1
Jan 2012	7	1	0
Feb 2012	3	2	2
Mar 2012	4	0	0
Apr 2012	10	3	2
May 2012	5	1	5
Jun 2012	7	3	4
Jul 2012	8	5	6
Aug 2012	7	2	3
Sep 2012	1	2	1
Oct 2012	17	5	8
Nov 2012	22	5	3
Dec 2012	10	2	3
Jan 2013	29	7	2
Feb 2013	12	3	3
Mar 2013	11	2	1
Apr 2013	12	4	4
May 2013	11	5	6
Jun 2013	2	5	2
Jul 2013	4	2	2
Aug 2013	5	3	4
Sep 2013	9	3	2
Oct 2013	6	5	6
Nov 2013	9	2	8
Dec 2013	7	3	6
Jan 2014	6	3	6
Feb 2014	3	3	8
Mar 2014	10	8	4
Apr 2014	12	10	8
May 2014	5	19	19
Jun 2014	4	12	10
Jul 2014	10	2	12
Aug 2014	4	7	4
Sep 2014	6	6	6
Oct 2014	4	4	8
Nov 2014	6	2	7
Dec 2014	8	5	5
Jan 2015	7	5	5
Feb 2015	1	2	1
Mar 2015	9	10	9
Apr 2015	2	2	3
May 2015	8	3	12
Jun 2015	1	4	8
Jul 2015	4	6	7
Aug 2015	1	3	6
Sep 2015	5	5	4
Oct 2015	3	1	5
Nov 2015	6	3	6
Dec 2015	4	3	6
Jan 2016	105	3	6
Feb 2016	12	2	3
Mar 2016	11	4	7
Apr 2016	7	3	5
May 2016	6	3	6
Jun 2016	5	4	9
Jul 2016	4	8	16
Aug 2016	5	2	8
Sep 2016	10	0	9
Oct 2016	9	0	7
Nov 2016	10	1	5
Dec 2016	5	2	6
Jan 2017	7	4	8
Feb 2017	0	2	2
Mar 2017	0	7	5
Apr 2017	0	9	0
May 2017	0	9	1
Jun 2017	4	9	8
Jul 2017	9	9	7
Aug 2017	9	9	3
Sep 2017	20	20	5
Oct 2017	16	16	1
Nov 2017	18	18	0
Dec 2017	3	3	1
Jan 2018	18	18	5
Feb 2018	14	12	1
Mar 2018	16	12	7
Apr 2018	67	65	2
May 2018	74	71	3
Jun 2018	40	26	1
Jul 2018	22	18	5
Aug 2018	43	41	4
Sep 2018	24	24	3
Oct 2018	65	64	5
Nov 2018	55	55	3
Dec 2018	67	67	2
Jan 2019	45	45	1
Feb 2019	43	41	8
Mar 2019	14	14	3
Apr 2019	8	8	7
May 2019	7	7	4
Jun 2019	2	2	2
Jul 2019	4	4	5
Aug 2019	4	2	4
Sep 2019	0	0	3
Oct 2019	9	7	5
Nov 2019	5	5	5
Dec 2019	11	5	5
Jan 2020	12	12	12
Feb 2020	3	3	2
Mar 2020	5	5	2
Apr 2020	2	2	1
May 2020	8	7	3
Jun 2020	7	6	4
Jul 2020	5	5	2
Aug 2020	1	1	3
Sep 2020	11	11	1
Oct 2020	12	12	3
Nov 2020	13	9	6
Dec 2020	41	30	1
Jan 2021	16	15	7
Feb 2021	9	9	3
Mar 2021	18	18	4
Apr 2021	4	6	3
May 2021	5	5	2
Jun 2021	6	6	0
Jul 2021	4	4	6
Aug 2021	7	7	7
Sep 2021	11	11	7
Oct 2021	278	278	16
Nov 2021	13	11	16
Dec 2021	4	4	4
Jan 2022	8	8	3
Feb 2022	5	5	3
Mar 2022	12	9	11
Apr 2022	63	63	3
May 2022	22	19	10
Jun 2022	32	26	8
Jul 2022	11	11	6
Aug 2022	30	30	6
Sep 2022	18	18	8
Oct 2022	33	33	9
Nov 2022	19	14	6
Dec 2022	10	6	5
Jan 2023	13	11	5
Feb 2023	29	29	2
Mar 2023	6	7	5
Apr 2023	7	6	4
May 2023	8	8	5
Jun 2023	5	5	3
Jul 2023	6	6	3
Aug 2023	7	7	6
Sep 2023	20	20	2
Oct 2023	112	112	2
Nov 2023	211	209	1
Dec 2023	34	7	0
Jan 2024	27	1	2
Feb 2024	24	0	0
Mar 2024	117	3	0
Apr 2024	36	1	0
May 2024	24	0	0
Jun 2024	32	0	1
Jul 2024	26	1	2
Aug 2024	50	1	1
Sep 2024	25	1	1
Oct 2024	38	0	0
Nov 2024	23	0	0
Total	4173	3752	1196

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