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Interpreting epidemiological research: blinded comparison of methods used to estimate the prevalence of inherited mutations inBRCA1
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    Importance of Blinded Comparisons

    Dear Editor

    Although I lack expertise in screening methods designed to detect the presence of mutations that predispose to disease, the findings reported on BRCA1 by Eng et al. are clearly important. It is essential that a systematic blinded comparison of methods should be carried out to establish or confirm the validity of genetic screening tests. This is of particular importance in cases where the predisposing ris...

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    Conflict of Interest:
    None declared.