Increase of FMRP expression, raised levels ofFMR1 mRNA, and clonal selection in proliferating cells with unmethylated fragile X repeat expansions: a clue to the sex bias in the transmission of full mutations?

Ulrike Salat; Barbara Bardoni; Doris Wöhrle; Peter Steinbach

doi:10.1136/jmg.37.11.842

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Original article

Increase of FMRP expression, raised levels ofFMR1 mRNA, and clonal selection in proliferating cells with unmethylated fragile X repeat expansions: a clue to the sex bias in the transmission of full mutations?

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	Abstract	Full	Pdf
Nov 2000	14	88	33
Dec 2000	4	38	20
Jan 2001	0	14	6
Feb 2001	0	27	10
Mar 2001	8	44	19
Apr 2001	6	21	6
May 2001	2	15	3
Jun 2001	2	16	2
Jul 2001	1	16	1
Aug 2001	0	21	4
Sep 2001	6	10	4
Oct 2001	2	20	4
Nov 2001	2	16	2
Dec 2001	2	3	0
Jan 2002	2	13	1
Feb 2002	3	18	5
Mar 2002	2	22	3
Apr 2002	4	39	3
May 2002	2	21	4
Jun 2002	1	10	4
Jul 2002	3	9	4
Aug 2002	2	7	4
Sep 2002	1	7	9
Oct 2002	2	5	0
Nov 2002	3	7	6
Dec 2002	1	7	3
Jan 2003	4	9	2
Feb 2003	1	9	3
Mar 2003	1	16	1
Apr 2003	0	9	4
May 2003	4	13	0
Jun 2003	3	5	2
Jul 2003	8	72	9
Aug 2003	13	18	4
Sep 2003	9	18	2
Oct 2003	11	50	5
Nov 2003	17	17	3
Dec 2003	8	21	2
Jan 2004	23	73	4
Feb 2004	10	18	8
Mar 2004	15	22	2
Apr 2004	15	17	6
May 2004	40	66	7
Jun 2004	40	76	9
Jul 2004	51	61	11
Aug 2004	35	55	8
Sep 2004	32	41	9
Oct 2004	24	32	9
Nov 2004	34	37	10
Dec 2004	18	31	6
Jan 2005	19	58	12
Feb 2005	13	48	8
Mar 2005	16	45	7
Apr 2005	6	22	7
May 2005	5	28	8
Jun 2005	5	27	11
Jul 2005	8	23	8
Aug 2005	7	20	7
Sep 2005	12	44	9
Oct 2005	18	42	9
Nov 2005	4	25	6
Dec 2005	7	21	8
Jan 2006	3	34	13
Feb 2006	4	17	8
Mar 2006	5	23	8
Apr 2006	8	14	8
May 2006	4	23	7
Jun 2006	2	13	3
Jul 2006	7	13	8
Aug 2006	3	23	9
Sep 2006	10	17	14
Oct 2006	6	17	11
Nov 2006	6	22	12
Dec 2006	7	28	7
Jan 2007	8	29	17
Feb 2007	3	17	10
Mar 2007	4	24	12
Apr 2007	6	11	7
May 2007	5	9	8
Jun 2007	7	3	2
Jul 2007	4	7	3
Aug 2007	5	6	6
Sep 2007	10	6	8
Oct 2007	5	3	2
Nov 2007	10	8	4
Dec 2007	6	5	5
Jan 2008	4	9	5
Feb 2008	8	8	3
Mar 2008	10	8	5
Apr 2008	6	8	7
May 2008	4	3	1
Jun 2008	6	2	1
Jul 2008	2	2	1
Aug 2008	14	5	1
Sep 2008	18	6	4
Oct 2008	15	1	2
Nov 2008	10	3	4
Dec 2008	6	4	1
Jan 2009	5	1	1
Feb 2009	16	7	6
Mar 2009	12	1	0
Apr 2009	5	0	2
May 2009	8	0	0
Jun 2009	11	1	0
Jul 2009	13	0	2
Aug 2009	11	0	0
Sep 2009	7	1	0
Oct 2009	9	4	3
Nov 2009	12	3	1
Dec 2009	9	2	1
Jan 2010	8	2	2
Feb 2010	4	0	1
Mar 2010	7	4	2
Apr 2010	8	4	4
May 2010	5	6	3
Jun 2010	8	2	3
Jul 2010	9	1	3
Aug 2010	10	3	3
Sep 2010	9	3	4
Oct 2010	22	9	1
Nov 2010	11	3	2
Dec 2010	15	12	0
Jan 2011	20	8	0
Feb 2011	12	10	2
Mar 2011	12	10	3
Apr 2011	15	3	2
May 2011	15	3	0
Jun 2011	5	8	0
Jul 2011	6	3	3
Aug 2011	15	6	3
Sep 2011	17	2	1
Oct 2011	8	7	0
Nov 2011	13	10	4
Dec 2011	5	25	3
Jan 2012	5	27	3
Feb 2012	8	21	1
Mar 2012	13	23	5
Apr 2012	5	35	9
May 2012	8	61	6
Jun 2012	4	14	4
Jul 2012	7	18	6
Aug 2012	9	20	6
Sep 2012	7	18	6
Oct 2012	14	18	16
Nov 2012	14	24	9
Dec 2012	10	9	8
Jan 2013	16	24	10
Feb 2013	6	18	7
Mar 2013	8	36	10
Apr 2013	15	26	12
May 2013	5	18	14
Jun 2013	5	17	7
Jul 2013	11	16	4
Aug 2013	6	9	4
Sep 2013	14	18	5
Oct 2013	10	13	4
Nov 2013	9	12	5
Dec 2013	12	5	7
Jan 2014	9	13	9
Feb 2014	9	15	6
Mar 2014	10	8	3
Apr 2014	16	12	7
May 2014	14	18	8
Jun 2014	3	11	8
Jul 2014	8	25	1
Aug 2014	3	38	4
Sep 2014	7	30	7
Oct 2014	6	9	4
Nov 2014	3	6	4
Dec 2014	9	6	4
Jan 2015	10	2	4
Feb 2015	6	2	6
Mar 2015	7	7	3
Apr 2015	20	6	8
May 2015	7	3	2
Jun 2015	3	8	7
Jul 2015	5	4	2
Aug 2015	4	4	2
Sep 2015	7	5	5
Oct 2015	1	2	2
Nov 2015	11	6	4
Dec 2015	6	7	5
Jan 2016	26	6	5
Feb 2016	10	8	2
Mar 2016	12	8	11
Apr 2016	9	3	4
May 2016	2	10	12
Jun 2016	4	18	2
Jul 2016	11	6	0
Aug 2016	11	3	1
Sep 2016	12	11	5
Oct 2016	14	13	3
Nov 2016	17	5	2
Dec 2016	9	25	4
Jan 2017	8	9	2
Feb 2017	2	11	2
Mar 2017	7	12	0
Apr 2017	1	19	2
May 2017	1	27	1
Jun 2017	10	22	4
Jul 2017	6	6	1
Aug 2017	16	15	2
Sep 2017	32	30	5
Oct 2017	35	25	4
Nov 2017	33	19	0
Dec 2017	16	12	1
Jan 2018	30	22	3
Feb 2018	24	20	1
Mar 2018	19	15	3
Apr 2018	20	14	2
May 2018	18	18	0
Jun 2018	38	32	2
Jul 2018	27	17	3
Aug 2018	38	28	3
Sep 2018	12	12	4
Oct 2018	75	75	1
Nov 2018	70	70	1
Dec 2018	104	100	3
Jan 2019	86	85	2
Feb 2019	82	80	4
Mar 2019	51	49	10
Apr 2019	23	22	2
May 2019	18	17	2
Jun 2019	9	8	3
Jul 2019	13	11	5
Aug 2019	8	6	3
Sep 2019	19	19	7
Oct 2019	11	10	2
Nov 2019	10	8	2
Dec 2019	20	19	5
Jan 2020	25	24	2
Feb 2020	8	7	4
Mar 2020	8	8	8
Apr 2020	6	6	1
May 2020	8	8	2
Jun 2020	7	5	10
Jul 2020	17	13	3
Aug 2020	2	2	4
Sep 2020	14	12	2
Oct 2020	31	30	12
Nov 2020	16	12	3
Dec 2020	16	13	3
Jan 2021	17	17	5
Feb 2021	7	6	7
Mar 2021	9	8	2
Apr 2021	4	4	3
May 2021	13	12	3
Jun 2021	7	7	2
Jul 2021	17	17	1
Aug 2021	15	14	1
Sep 2021	13	12	5
Oct 2021	11	11	16
Nov 2021	10	11	13
Dec 2021	15	15	2
Jan 2022	7	8	6
Feb 2022	20	22	6
Mar 2022	16	15	4
Apr 2022	21	20	10
May 2022	21	21	6
Jun 2022	24	24	5
Jul 2022	21	19	4
Aug 2022	22	22	3
Sep 2022	20	18	6
Oct 2022	28	30	7
Nov 2022	11	9	5
Dec 2022	8	6	2
Jan 2023	15	14	4
Feb 2023	27	27	1
Mar 2023	11	12	4
Apr 2023	3	3	3
May 2023	9	9	10
Jun 2023	13	4	3
Jul 2023	12	12	6
Aug 2023	9	7	8
Sep 2023	8	7	3
Oct 2023	11	11	3
Nov 2023	16	16	3
Dec 2023	44	1	0
Jan 2024	22	2	2
Feb 2024	57	0	0
Mar 2024	25	0	1
Total	3560	4738	1338

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