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Methylenetetrahydrofolate reductase polymorphism and pre-eclampsia.
  1. S Sohda,
  2. T Arinami,
  3. H Hamada,
  4. N Yamada,
  5. H Hamaguchi,
  6. T Kubo
  1. Department of Obstetrics and Gynaecology, University of Tsukuba, Ibaraki, Japan.


    A common missense mutation in the methylenetetrahydrofolate reductase (MTHFR) gene, a C to T substitution at nucleotide 677, is responsible for reduced MTHFR activity and associated with modestly increased plasma homocysteine concentrations. Since underlying maternal vascular disease increases the risk of pre-eclampsia, we had the working hypothesis that pre-eclampsia patients would have an increased T677 allele frequency compared with controls. The MTHFR genotypes were determined in 67 pre-eclampsia patients, 98 normal pregnant women, and 260 healthy adults by the PCR/RFLP method. The T677 allele and the genotype homozygous for the T677 allele were significantly increased in the pre-eclamptic group compared with the controls (p < 0.02 and p < 0.004, respectively). The data indicate that the T677 variant of the MTHFR gene is one of the genetic risk factors for pre-eclampsia.

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