Article Text

Download PDFPDF

Confirmation of linkage of Sjögren-Larsson syndrome to chromosome 17 in families of different ethnic origins.
  1. M Lacour,
  2. H R Middleton-Price,
  3. J I Harper
  1. Department of Dermatology, Great Ormond Street Hospital for Children, London, UK.

    Abstract

    Linkage analysis in two consanguineous pedigrees of Pakistani and English origin and one further Indian family in which affected subjects have Sjögren-Larsson syndrome (SLS) showed linkage to chromosome 17. Linkage of SLS to D17S783 and D17S805 has been reported in Swedish pedigrees, but since those data were generated from a single ethnic group originating from a common ancestor, there remained the question of whether this disease is genetically heterogeneous. This report confirms the linkage in non-Swedish pedigrees and, therefore, provides evidence to support a single locus for SLS.

    Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.