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Molecular scanning of candidate mitochondrial tRNA genes in type 2 (non-insulin dependent) diabetes mellitus.
  1. A W Thomas,
  2. A Edwards,
  3. E J Sherratt,
  4. A Majid,
  5. J Gagg,
  6. J C Alcolado
  1. Department of Medicine, University Hospital of Wales, Heath Park, Cardiff, UK.


    Mitochondrial DNA (mtDNA) gene defects may play a role in the development of non-insulin dependent diabetes mellitus (NIDDM). In order to search for potentially diabetogenic mtDNA defects we have applied the technique of single stranded conformational polymorphism (SSCP) analysis to 124 patients with a history of NIDDM and 40 non-diabetic controls. No new heteroplasmic mutations were detected. However, a variety of homoplasmic variants were found in patients with NIDDM; some of these merit further investigation.

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