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Exclusion of one pedigree affected by adult onset primary open angle glaucoma from linkage to the juvenile glaucoma locus on chromosome 1q21-q31.
  1. D Avramopoulos,
  2. G Kitsos,
  3. E Economou-Petersen,
  4. M Grigoriadou,
  5. D Vassilopoulos,
  6. C Papageorgiou,
  7. K Psilas,
  8. M B Petersen
  1. Department of Genetics, Institute of Child Health, Athens, Greece.


    A locus for autosomal dominant juvenile onset primary open angle glaucoma (POAG) was recently assigned to chromosome region 1q21-q31. In the present study, a large Greek family with autosomal dominant adult onset POAG was investigated using microsatellite markers. Exclusion of linkage of the adult onset POAG gene to the region D1S194-D1S191 was obtained in this pedigree. Therefore, the data provide evidence that juvenile and adult onset POAG are genetically distinct disease entities.

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