You are here

Article Text

Article menu
Download PDFPDF
Research Article
Genetic aspects of antibiotic induced deafness: mitochondrial inheritance.
  1. D N Hu,
  2. W Q Qui,
  3. B T Wu,
  4. L Z Fang,
  5. F Zhou,
  6. Y P Gu,
  7. Q H Zhang,
  8. J H Yan,
  9. Y Q Ding,
  10. H Wong
  1. Department of Genetic Counselling, Tiedao Medical College, Shanghai, China.

    Abstract

    Analysis of 36 pedigrees with a positive family history of aminoglycoside antibiotic induced deafness, ascertained in a population of 483,611 in Zhabei District in Shanghai, showed that the susceptibility to antibiotic ototoxicity was transmitted by females exclusively, indicating mitochondrial inheritance. Reanalysis of 18 other published pedigrees confirmed this conclusion.

    https://doi.org/10.1136/jmg.28.2.79

    Statistics from Altmetric.com

      Request Permissions

      If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.