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Linkage studies and deletion screening in choroideremia.
  1. A F Wright,
  2. R L Nussbaum,
  3. S S Bhattacharya,
  4. M Jay,
  5. J G Lesko,
  6. H J Evans,
  7. B Jay
  1. MRC Human Genetics Unit, Western General Hospital, Edinburgh.


    Fourteen families with choroideremia (TCD) have been examined for linkage to nine genetic markers located on the proximal long arm of the X chromosome. Linkage to three markers (DXYS1, DXS72, DXS3) located in Xq21 was found with a four point lod score of 8.25. No evidence of submicroscopic deletions was observed using DXS233 and DXS232, both thought to lie within about 1 Mb of the TCD gene.

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