Article Text

Download PDFPDF
No evidence for genetic linkage of Gilles de la Tourette syndrome on chromosomes 7 and 18.
  1. P Heutink,
  2. B J van de Wetering,
  3. G J Breedveld,
  4. J Weber,
  5. L A Sandkuyl,
  6. E J Devor,
  7. A Heiberg,
  8. M F Niermeijer,
  9. B A Oostra
  1. Department of Clinical Genetics, Erasmus University, Rotterdam, The Netherlands.


    Gilles de la Tourette syndrome is a heritable neuropsychiatric disorder. In order to determine the chromosomal localisation of the locus involved, genetic linkage studies were initiated in six extended families. The Gilles de la Tourette gene has been tentatively assigned to chromosome 18q22.1. In our present study no evidence for genetic linkage on chromosome 18 and chromosome 7 was obtained. Data from the markers tested made it possible to exclude the whole of chromosome 18 and the chromosome 7q21.3-qter region as a site for the Gilles de la Tourette gene.

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.