Article Text

Download PDFPDF
X linked neonatal myotubular myopathy: one recombination detected with four polymorphic DNA markers from Xq28.
  1. A E Lehesjoki,
  2. E M Sankila,
  3. J Miao,
  4. M Somer,
  5. R Salonen,
  6. J Rapola,
  7. A de la Chapelle
  1. Department of Medical Genetics, University of Helsinki, Finland.


    A three generation family with X linked myotubular myopathy (MTM1) was studied with several polymorphic markers from the distal long arm of the X chromosome. A recombination between the disease gene and four markers (loci DXS52, DXS134, DXS15, F8C) from the Xq28 cluster was detected. A new polymorphic marker (U6.2) defining the locus DXS304 in the Xq27-28 region proximal to the Xq28 cluster did not show any recombination with MTM1. These results suggest the following order of loci in distal Xq: cen-DXS42-DXS105-(DXS304, MTM1)-(DXS52, DXS134, DXS15, F8C)-tel.

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.