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Microphthalmia with single central incisor and hypopituitarism.
  1. H G Artman,
  2. E Boyden
  1. Department of Pediatrics, University of Nevada School of Medicine, Reno 89557.


    A patient is described with a new association of microphthalmia, single central incisor, and hypopituitarism believed to represent a holoprosencephaly malformation. In view of the genetic ramifications of this malformation and its variable manifestations, we would like to alert the clinician to consider holoprosencephaly whenever midline malformations are detected.

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