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Monozygotic twins with trisomy 18: a report of discordant phenotype.
  1. J S Schlessel,
  2. W T Brown,
  3. A Lysikiewicz,
  4. R Schiff,
  5. A L Zaslav
  1. Department of Pediatrics, North Shore University Hospital-Cornell University Medical College, Manhasset, New York 11030.


    The predicted incidence of liveborn monozygotic trisomy 18 twins is one per million births. The first case of liveborn monozygotic trisomy 18 twins was reported in 1989 and we report a second case in which striking phenotypic discordance existed. The probability of monozygotic trisomy 18 twinning and the mechanisms for phenotypic discordance in trisomic twins is discussed.

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