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Severe Silver-Russell syndrome.
  1. D Donnai,
  2. E Thompson,
  3. J Allanson,
  4. M Baraitser
  1. Regional Genetic Service, St Mary's Hospital, Manchester.


    Three children are described with severe Silver-Russell syndrome. Major medical problems occurred in the first two years of life in all three. Silver-Russell syndrome should be considered in the differential diagnosis of children with severe pre- and postnatal growth deficiency.

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