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Dominantly inherited cleft lip and palate in two families.
  1. K Temple,
  2. M Calvert,
  3. D Plint,
  4. E Thompson,
  5. M Pembrey
  1. Department of Paediatric Genetics, Institute of Child Health, London.


    Two families with non-syndromic cleft lip and cleft palate are described. The linear pattern of inheritance through several generations is difficult to explain by conventional multifactorial models. The pedigrees strengthen the suggestion that a dominantly inherited mutation exists with a major influence on clefting of the lip and palate alone.

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