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Chromosome studies of males in an institution for the mentally handicapped.
  1. C J English,
  2. E V Davison,
  3. M S Bhate,
  4. L Barrett
  1. Department of Human Genetics, University of Newcastle upon Tyne.


    Karyotypes were examined in 512 (91.9%) of 557 male patients in an institution for the mentally handicapped. A total of 110 (21.5%) had an abnormal karyotype: 65 (12.7%) with Down's syndrome, 30 (5.9%) with the fragile X syndrome, 13 (2.5%) with autosomal anomalies other than Down's syndrome (12 unbalanced, one balanced), and two (0.4%) with sex chromosome anomalies.

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