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Is there an autosomal recessive form of the split hand and split foot malformation?
  1. J Zlotogora,
  2. N Nubani
  1. Department of Human Genetics, Hadassah Medical Centre, Hebrew University, Jerusalem, Israel.


    A family is described in which four subjects in two sibships had typical split hand/foot malformation. The possibility of the existence of a rare autosomal recessive form of the malformation is discussed, as well as a two locus model. In the two locus model the dominant mutation leading to the split hand/foot malformation is controlled by a gene at another locus. A dominant mutation at the controlling locus leads to non-penetrance of the split hand/foot mutation.

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