Article Text

Download PDFPDF
Increased sharing of maternal HLA haplotypes among children exposed to diphenylhydantoin during pregnancy.
  1. S E Hodge,
  2. D C Van Dyke,
  3. A S Goldman,
  4. F Heide,
  5. R Hill,
  6. C M Zmijewski
  1. Department of Biomathematics, UCLA School of Medicine.


    During investigation of HLA types among children exposed to diphenylhydantoin (DPH) in utero, we found no evidence of a distortion in haplotype sharing among affected sib pairs. Unexpectedly, however, we found a marked increase in the proportion of all sib pairs (not just affected ones) sharing maternal haplotypes. Among 14 two child families, 12 shared the maternal haplotype (expected would be seven); among families with more than two children the distortion was also pronounced. This finding, if verified in future studies, could indicate that something in the mothers, whether DPH use during pregnancy, or some genetic factor associated with seizures, or some effect of the seizures themselves, may be leading to non-random segregation of HLA haplotypes in their offspring.

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.