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A deletion of one nucleotide results in functional deficiency of apolipoprotein CII (apo CII Toronto).
  1. D W Cox,
  2. D E Wills,
  3. F Quan,
  4. P N Ray
  1. Research Institute, Hospital for Sick Children, Toronto, Canada.


    Apolipoprotein CII Toronto is a mutant non-functional apo CII resulting in apo CII deficiency. A portion of the mutant apo CII gene was cloned into lambda gt10 and subclones were sequenced. A deletion of one base was found in the codon for amino acid Thr68, resulting in alteration of six amino acids and premature termination of the protein at amino acid 74.

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