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Linkage of the tuberous sclerosis locus to a DNA polymorphism detected by v-abl.
  1. J M Connor,
  2. L A Pirrit,
  3. J R Yates,
  4. A E Fryer,
  5. M A Ferguson-Smith
  1. Duncan Guthrie Institute of Medical Genetics, Yorkhill, Glasgow.


    Linkage analysis was undertaken in six families with tuberous sclerosis (TS) using a restriction fragment length polymorphism detected by v-abl. No recombinants were observed in 13 informative meioses (four phase known) giving a maximum lod score of 3.18 at zero recombination (confidence limits 0 to 0.15). This provides further evidence for the assignment of TS to 9q34 and should facilitate cloning of the structural gene, genetic counselling, and first trimester prenatal diagnosis.

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