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Linkage analysis of peripheral neurofibromatosis to DNA markers on chromosome 8.
  1. S R Diehl,
  2. M Boehnke,
  3. F S Collins,
  4. R P Erickson,
  5. I J Karolyi,
  6. L M Ploughman,
  7. M A Pericak-Vance,
  8. A S Aylsworth,
  9. A D Roses
  1. Department of Human Genetics, University of Michigan, Ann Arbor 48109-0618.


    Linkage relationships of the gene for peripheral neurofibromatosis (NF) were assessed in a large American Caucasian pedigree using two DNA markers located on chromosome 8. Linkage to the thyroglobulin locus, located at 8q24, was excluded (lod less than or equal to -2.0) to 21 cM. Data obtained for the tissue plasminogen activator locus, located at 8p12, excluded linkage to 4 cM. These results exclude between 20 to 30% of chromosome 8 as a possible map location for the NF gene in this family. Comparison of the two DNA markers excluded their linkage to 0.5 cM.

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