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Linkage analysis of neurofibromatosis.
  1. S Kittur,
  2. M L Lubs,
  3. M Bauer,
  4. A Chakravarti,
  5. H Kazazian
  1. Department of Pediatrics, Johns Hopkins Institution, Baltimore, Maryland.


    Linkage analysis of neurofibromatosis was performed using genes on chromosomes 1, 8, 11, and 12. No linkage was found between NF and C-myc, AT 3, IGF-1, PTH, and gamma globin genes. Evidence for linkage was found between C-ets 1, on the long arm of chromosome 11 and NF in two families with a lod score of 1.88 at theta = 0. More families are being studied to confirm this linkage.

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