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Adult polycystic kidney disease and linked RFLPs at the alpha globin locus: a genetic study in the South Wales population.
  1. L P Lazarou,
  2. F Davies,
  3. M Sarfarazi,
  4. G A Coles,
  5. P S Harper
  1. Institute of Medical Genetics, University of Wales College of Medicine, Health Park, Cardiff.


    Thirteen South Wales kindreds with adult polycystic kidney disease have been studied for genetic linkage using the alpha globin and 3'HVR probes. A maximum lod score of 24.187 was found at a recombination fraction of 0.03. This study supports the existence of a single locus on chromosome 16 responsible for the disorder.

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